Mixed-phenotype acute leukemia

Chhandama: added Category:Hematologic malignant neoplasms using HotCat

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'''Mixed-phenotype acute leukemia''' is a group of blood cancers ([[leukemia]]) which have combined features of [[Myeloid leukemia|myeloid]] and [[Lymphoid leukemia|lymphoid cancers]]. It is a rare disease, constituting about 2–5% of all leukemia cases.<ref name="weinberg10">Liquid error: wrong number of arguments (given 1, expected 2)</ref> It mostly involve myeloid with either of [[T cell|T lymphocyte]] or [[B cell|B lymphocyte]] progenitors, but in rare cases all the three cell lineages.<ref name="kim16">Liquid error: wrong number of arguments (given 1, expected 2)</ref> Knowledge on the cause, clinical features and cellular mechanism is poor, making the treatment and management (prognosis) difficult.<ref name="cernan17">Liquid error: wrong number of arguments (given 1, expected 2)</ref>

The name "mixed-phenotype acute leukemia" was adopted by the World Health Organization in 2008 (in ''WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues'') to include leukemias of ambiguous lineage, acute undifferentiated leukemias and natural killer lymphoblastic leukemias.<ref name="bene12">Liquid error: wrong number of arguments (given 1, expected 2)</ref> According to WHO criteria, myeloid lineage is characterised by the presence of [[myeloperoxidase]], while B and T lymphoid lineages are indicated by the expression of [[CD19]] and cytoplasmic [[CD3]].<ref name="khan18">Liquid error: wrong number of arguments (given 1, expected 2)</ref>

==References==


[[Category:Acute leukemia]]
[[Category:Hematologic malignant neoplasms]]

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