Genetics4good: Merged content from Base Editors to here. See Talk:Base Editors.
'''DNA‐templated organic synthesis''' (DTS) is a way to control the reactivity of synthetic molecules by using nature's molarity‐based approach. Hostorically, DTS was used as a model of prebiotic nucleic acid replication. Now however, it is capable of translating DNA sequences into complex small‐molecule and polymer products of multistep organic synthesis.<ref>[http://bit.ly/2SvSnFI Controlling Chemical Reactivity Applied to Synthetic Molecules]</ref>
==Base Editors==
The '''DNA base editors''', developed at [[Harvard University]] under [[David_R._Liu|David Liu]], allow altering the genomic structure of DNA. The base editors include BE3, BE4 and ABE7.
BE3 (and its later version, BE4) allow to change the nucleobase C to T and nucleobase G to A.
ABE7 allows to change A-T base pairs into G-C base pairs.
The system works by rearranging the atoms in the target base pair and then tricking cells into fixing the other DNA strand to make the change permanent.<ref>[http://bit.ly/2y6NqnO A step forward in DNA base editing]</ref><ref>[http://bit.ly/2yQh5FH We’ve evolved an even more powerful form of CRISPR gene editing]</ref><ref>[http://bit.ly/2DEeW0y Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction.]</ref><ref>[https://go.nature.com/2jwxiKN Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage]</ref>
==References==
[[Category:Biological engineering]]
[[Category:Biotechnology]]
[[Category:Emerging technologies]]
[[Category:Genetic engineering|*]]
[[Category:Genome editing]]
[[Category:Molecular biology]]
==Base Editors==
The '''DNA base editors''', developed at [[Harvard University]] under [[David_R._Liu|David Liu]], allow altering the genomic structure of DNA. The base editors include BE3, BE4 and ABE7.
BE3 (and its later version, BE4) allow to change the nucleobase C to T and nucleobase G to A.
ABE7 allows to change A-T base pairs into G-C base pairs.
The system works by rearranging the atoms in the target base pair and then tricking cells into fixing the other DNA strand to make the change permanent.<ref>[http://bit.ly/2y6NqnO A step forward in DNA base editing]</ref><ref>[http://bit.ly/2yQh5FH We’ve evolved an even more powerful form of CRISPR gene editing]</ref><ref>[http://bit.ly/2DEeW0y Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction.]</ref><ref>[https://go.nature.com/2jwxiKN Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage]</ref>
==References==
[[Category:Biological engineering]]
[[Category:Biotechnology]]
[[Category:Emerging technologies]]
[[Category:Genetic engineering|*]]
[[Category:Genome editing]]
[[Category:Molecular biology]]
from Wikipedia - New pages [en] http://bit.ly/2DCUcqc
via IFTTT
No comments:
Post a Comment