Achim Raschka: /* Life and career */
'''John Patrick Morrissey''' is an [[Ireland|Irish]] [[microbiology|microbiologist]] and [[biotechnology|biotechnologist]]. Since 2000 he has worked and taught as Professor of Microbiology at [[University College Cork]] (UCC), Ireland. Recently he works mainly on the optimisation of [[yeast]]s for [[industrial biotechnology]], but is also involved in the works with several other organisms.
== Life and career ==
John Morrissey studied microbiology at University College Cork, graduating with a bachelor's degree in science in 1990. After graduating, he moved to the [[European Molecular Biology Laboratory]] (EMBL) in [[Heidelberg]], Germany, where he worked in [[David Tollervey]]'s group on his doctoral thesis in the field of yeast molecular biology, in particular on specific [[snRNA]] and the formation of [[rRNA]] in ''[[Saccharomyces cerevisiae]]''.<ref name="Henry et al. 1994">Yves Henry, Heather Wood, John P. Morrissey, Elisabeth Petfalski, Stephen Kearsey, David Tollervey: ''The 5′ end of yeast 5.8 S rRNA is generated by exonucleases from an upstream cleavage site.'' The EMBO journal 13 (10), 1994; S. 2452-2463. ([https://ift.tt/2UqYZFx full text]).</ref><ref name="Morrissey & Tollervey 1994">John P. Morrissey, David Tollervey: ''Yeast snR30 is a small nucleolar RNA required for 18S rRNA synthesis.'' Molecular and Cellular Biology 13 (4), 1994; S. 2469-2477. ([https://ift.tt/2JUclpE full text]).</ref><ref name="Morrissey & Tollervey 1995">John P. Morrissey, David Tollervey: ''Birth of the snoRNPs: the evolution of RNase MRP and the eukaryotic pre-rRNA-processing system.'' Trends in Biochemical Sciences 20 (2), 1995; S. 78-82. .</ref> He received his doctorate in 1994 for his work and was a postdoctoral fellow at the [[University of California, Berkeley]], in the United States from 1995 to 1997.<ref name="Morrissey UCC">''[https://ift.tt/2UwShOt John Morrissey]'', biography at University College Cork.</ref>
From 1998 to 2000 he worked and researched at the [[John Innes Centre]] (JIC) in [[Norwich]], UK, and dealt with [[drug resistance]] of fungi to [[antibiotics|antibiotics]] produced by plants and with natural [[fungicides]] from [[bacteria]].<ref name="Morrissey & Osbourn 1999">John P. Morrissey, Anne E. Osbourn: ''Fungal Resistance to Plant Antibiotics as a Mechanism of Pathogenesis.'' Microbiology and Molecular Biology Reviews 63 (3), September 1999; S. 708–724. ([https://ift.tt/2JUcmtI full text])</ref> He continued this work after moving to University College Cork in 2000, where he collaborated mainly with the Irish microbiologist [[Fergal O'Gara]] to investigate the interactions of root bacteria with their host plants and their fungicidal properties.<ref name="Walsh et al. 2001">Ultan F Walsh, John P Morrissey, Fergal O'Gara: ''Pseudomonas for biocontrol of phytopathogens: from functional genomics to commercial exploitation.'' Current Opinion in Biotechnology 12 (3), 2001; S. 289-295. , [https://ift.tt/2UqcrcI full text].</ref> Since 2003, Morrissey has led his own research group as Professor of Microbiology at the UCC, whose research focus initially continued the previous work. Morrissey also investigated the ecological relationships of bacteria in the root system of plants,<ref name="Mark et al. 2005">G. Louise Mark, J. Maxwell Dow, Patrick D. Kiely, Hazel Higgins, Jill Haynes, Christine Baysse, Abdelhamid Abbas, Tara Foley, Ashley Franks, John Morrissey, Fergal O'Gara: ''Transcriptome profiling of bacterial responses to root exudates identifies genes involved in microbe-plant interactions.'' Proceedings of the National Academy of Sciences 102 (48), 2005; S. 17454-17459. .</ref> the fungicidal effects of root-associated ''[[Pseudomonas]]'' species and their potential use in [[environmental biotechnology]]<ref name="Mark et al. 2006">Genevieve L. Mark, John P. Morrissey, P. Higgins, Fergal O'Gara: ''Molecular-based strategies to exploit Pseudomonas biocontrol strains for environmental biotechnology applications.'' FEMS Microbiology Ecology 56 (2), 2006; S. 167-177. .</ref> and general biochemical relationships between bacteria and fungi.<ref name="McAlester et al. 2008">Gordon McAlester, Fergal O'Gara, John P Morrissey: ''Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans.'' Journal of medical microbiology 57 (5), 2008; S. 563-569. .</ref> From 2010 onwards Morrissey was also working on the biotechnological use and [[metagenomics]] of marine organisms,<ref name="Kennedy 2010">Jonathan Kennedy, Burkhardt Flemer, Stephen A Jackson, David PH Lejon, John P Morrissey, Fergal O’gara, Alan DW Dobson: ''Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism.'' Marine Drugs 8 (3), 2010; S. 608-628. .</ref> especially of [[sponges]]n (Porifera),<ref name="Baker et al. 2010">P.W. Baker, J. Kennedy, J. Morrissey, Fergal O’Gara, A.D.W. Dobson, Julian Roberto Marchesi: ''Endoglucanase activities and growth of marine‐derived fungi isolated from the sponge Haliclona simulans.'' Journal of Applied Microbiology 108 (5), 2010; S. 1668-1675. .</ref> to which he also wrote several book chapters.<ref name="Kennedy et al. 2013">J. Kennedy, S.A. Jackson, J.P. Morrissey, F. O’Gara, A.D.W. Dobson: ''Marine Invertebrate Animal Metagenomics, Porifera.'' In: ''Encyclopedia of Metagenomics.'' Springer, New York City 2013.</ref><ref name="Jackson et al. 2013">S.A. Jackson, J. Kennedy, L.M. Margassery, B. Flemer, N.D. O’ Leary, J.P. Morrissey, F. O'Gara, A.D.W. Dobson: ''Marine sponges –Molecular Biology and Biotechnology.'' In: ''Handbook of Marine Biotechnology.'' Springer, New York City 2013.</ref>
His current research focus is on the molecular biology and microecology of yeasts and the use of genetically modified yeast cells for industrial biotechnology. Morrissey concentrates on the use of ''[[Kluyveromyces marxianus]]'''.<ref name="Lane & Morrissey 2010">M.M. Lane, J.P. Morrissey: ''[[Kluyveromyces marxianus]]: A yeast emerging from its sister's shadow.'' Fungal Biology Reviews 24 (1), 2010; S. 17–26. .</ref><ref name="Morrissey et al. 2015">John P. Morrissey, Maria M.W. Etschmann, Jens Schrader, Gustavo M. de Billerbeck: ''Cell factory applications of the yeast Kluyveromyces marxianus for the biotechnological production of natural flavour and fragrance molecules.'' Yeast 32 (1), 2015; S. 3-16. .</ref><ref name="Juergens et al. 2017">Hannes Juergens, Javier A. Varela, Arthur R. Gorter de Vries, Thomas Perli, Veronica J.M. Gast, Nikola Y. Gyurchev, Arun S. Rajkumar, Robert Mans, Jack T. Pronk, John P. Morrissey, Jean-Marc G. Daran: ''Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9/gRNA co-expression plasmid.'' FEMS Yeast Researc 18 (3), 2018; S. foy012. .</ref><ref name="Morrissey et al. 2018">J. Morrissey, J. Varela, R. Ortiz, K. Wolfe: ''Adaptation of the yeast Kluyveromyces marxianus to a biotechnological niche.'' New Biotechnology 44, S7.</ref> Among other projects he leads the European research projects YEASTCELL (until 2017),<ref name="yeastcell.eu">[https://yeastcell.eu Official Homepage] of the project „YEASTCELL“, assessed at 1. April 2019.</ref><ref name="YEASTCELL Cordis">''[https://ift.tt/2JVVpiF Yeast Cell Factories: Training Researchers to Apply Modern Post-Genomic Methods In Yeast Biotechnology (YEASTCELL)]'' in the European project database [[CORDIS]], assessed at 1. April 2019.</ref> YEASTDOC<ref name="yeastdoc.eu">[https://yeastdoc.eu Official Homepage] of the project „YEASTDOC“, assessed at 1. April 2019.</ref><ref name="YEASTDOC Cordis">''[https://ift.tt/2UncC8J Yeast Biotechnology Doctoral Training Programme (YEASTDOC)]'' in the European project database [[CORDIS]], assessed at 1. April 2019.</ref> and CHASSY<ref name="chassy.eu">[http://chassy.eu Official Homepage] of the project „CHASSY“, assessed at 1. April 2019.</ref><ref name="CHASSY Cordis">''[https://ift.tt/2K8vW5s Model-Based Construction And Optimisation Of Versatile Chassis Yeast Strains For Production Of Valuable Lipid And Aromatic Compounds (CHASSY)]'' in the European project database [[CORDIS]], assessed at 1. April 2019.</ref> with a focus on yeasts as production organisms.
== Awards and Functions ==
John P. Morrissey is a member of the [[Editorial Board]] of the journal [[FEMS Yeast Research]]. He is also a member and representative for Ireland of the International Commission on Yeasts (ICY) and was elected Chairman of the Eukaryotic Section of the [[Society for General Microbiology]] (SGM) from 2013 to 2017.<ref name="Morrissey UCC" />
== Publications (Selection) ==
John P. Morrissey regularly publishes articles on his research activities in scientific journals. These articles are original research contributions as well as review contributions on central topics of molecular biology and biotechnology<ref name="Morrissey UCC" /><ref name="Google Scholar">[https://ift.tt/2UoBvRf ''Publikationen von J. Morrissey''] at Google Scholar.</ref>
As a selection:
* Yves Henry, Heather Wood, John P. Morrissey, Elisabeth Petfalski, Stephen Kearsey, David Tollervey: ''The 5′ end of yeast 5.8 S rRNA is generated by exonucleases from an upstream cleavage site.'' The EMBO journal 13 (10), 1994; S. 2452–2463. ([https://ift.tt/2UqYZFx full text])
* John P. Morrissey, Anne E. Osbourn: ''Fungal Resistance to Plant Antibiotics as a Mechanism of Pathogenesis.'' Microbiology and Molecular Biology Reviews 63 (3), September 1999; S. 708–724.
* Ultan F. Walsh, John P. Morrissey, Fergal O'Gara: ''Pseudomonas for biocontrol of phytopathogens: from functional genomics to commercial exploitation.'' Current Opinion in Biotechnology 12 (3), 2001; S. 289–295.
* M.M. Lane, J.P. Morrissey: ''[[Kluyveromyces marxianus]]: A yeast emerging from its sister's shadow.'' Fungal Biology Reviews 24 (1), 2010; S. 17–26.
* Jonathan Kennedy, Burkhardt Flemer, Stephen A. Jackson, David P.H. Lejon, John P. Morrissey, Fergal O’Gara, Alan D.W. Dobson: ''Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism.'' Marine Drugs 8 (3), 2010; S. 608–628.
* Leonie Baumann, Arun S. Rajkumar, John P. Morrissey, [[Eckhard Boles]], Mislav Oreb: ''A Yeast-Based Biosensor for Screening of Short- and Medium-Chain Fatty Acid Production.'' ACS Synthetic Biology 7 (11), 2018; pp 2640–2646. .
== References ==
== External links ==
* ''[https://ift.tt/2UwShOt John Morrissey]'', biography at University College Cork (UCC)
* [https://ift.tt/2UoBvRf ''Publikationen von J. Morrissey''] at Google Scholar
* ''[https://ift.tt/2JUcr0u John Morrissey]'' at researchgate.net
[[Category:Living people]]
[[Category:University College Cork]]
[[Category:Irish microbiologists]]
[[Category:Irish geneticists]]
[[Category:Irish biologists]]
== Life and career ==
John Morrissey studied microbiology at University College Cork, graduating with a bachelor's degree in science in 1990. After graduating, he moved to the [[European Molecular Biology Laboratory]] (EMBL) in [[Heidelberg]], Germany, where he worked in [[David Tollervey]]'s group on his doctoral thesis in the field of yeast molecular biology, in particular on specific [[snRNA]] and the formation of [[rRNA]] in ''[[Saccharomyces cerevisiae]]''.<ref name="Henry et al. 1994">Yves Henry, Heather Wood, John P. Morrissey, Elisabeth Petfalski, Stephen Kearsey, David Tollervey: ''The 5′ end of yeast 5.8 S rRNA is generated by exonucleases from an upstream cleavage site.'' The EMBO journal 13 (10), 1994; S. 2452-2463. ([https://ift.tt/2UqYZFx full text]).</ref><ref name="Morrissey & Tollervey 1994">John P. Morrissey, David Tollervey: ''Yeast snR30 is a small nucleolar RNA required for 18S rRNA synthesis.'' Molecular and Cellular Biology 13 (4), 1994; S. 2469-2477. ([https://ift.tt/2JUclpE full text]).</ref><ref name="Morrissey & Tollervey 1995">John P. Morrissey, David Tollervey: ''Birth of the snoRNPs: the evolution of RNase MRP and the eukaryotic pre-rRNA-processing system.'' Trends in Biochemical Sciences 20 (2), 1995; S. 78-82. .</ref> He received his doctorate in 1994 for his work and was a postdoctoral fellow at the [[University of California, Berkeley]], in the United States from 1995 to 1997.<ref name="Morrissey UCC">''[https://ift.tt/2UwShOt John Morrissey]'', biography at University College Cork.</ref>
From 1998 to 2000 he worked and researched at the [[John Innes Centre]] (JIC) in [[Norwich]], UK, and dealt with [[drug resistance]] of fungi to [[antibiotics|antibiotics]] produced by plants and with natural [[fungicides]] from [[bacteria]].<ref name="Morrissey & Osbourn 1999">John P. Morrissey, Anne E. Osbourn: ''Fungal Resistance to Plant Antibiotics as a Mechanism of Pathogenesis.'' Microbiology and Molecular Biology Reviews 63 (3), September 1999; S. 708–724. ([https://ift.tt/2JUcmtI full text])</ref> He continued this work after moving to University College Cork in 2000, where he collaborated mainly with the Irish microbiologist [[Fergal O'Gara]] to investigate the interactions of root bacteria with their host plants and their fungicidal properties.<ref name="Walsh et al. 2001">Ultan F Walsh, John P Morrissey, Fergal O'Gara: ''Pseudomonas for biocontrol of phytopathogens: from functional genomics to commercial exploitation.'' Current Opinion in Biotechnology 12 (3), 2001; S. 289-295. , [https://ift.tt/2UqcrcI full text].</ref> Since 2003, Morrissey has led his own research group as Professor of Microbiology at the UCC, whose research focus initially continued the previous work. Morrissey also investigated the ecological relationships of bacteria in the root system of plants,<ref name="Mark et al. 2005">G. Louise Mark, J. Maxwell Dow, Patrick D. Kiely, Hazel Higgins, Jill Haynes, Christine Baysse, Abdelhamid Abbas, Tara Foley, Ashley Franks, John Morrissey, Fergal O'Gara: ''Transcriptome profiling of bacterial responses to root exudates identifies genes involved in microbe-plant interactions.'' Proceedings of the National Academy of Sciences 102 (48), 2005; S. 17454-17459. .</ref> the fungicidal effects of root-associated ''[[Pseudomonas]]'' species and their potential use in [[environmental biotechnology]]<ref name="Mark et al. 2006">Genevieve L. Mark, John P. Morrissey, P. Higgins, Fergal O'Gara: ''Molecular-based strategies to exploit Pseudomonas biocontrol strains for environmental biotechnology applications.'' FEMS Microbiology Ecology 56 (2), 2006; S. 167-177. .</ref> and general biochemical relationships between bacteria and fungi.<ref name="McAlester et al. 2008">Gordon McAlester, Fergal O'Gara, John P Morrissey: ''Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans.'' Journal of medical microbiology 57 (5), 2008; S. 563-569. .</ref> From 2010 onwards Morrissey was also working on the biotechnological use and [[metagenomics]] of marine organisms,<ref name="Kennedy 2010">Jonathan Kennedy, Burkhardt Flemer, Stephen A Jackson, David PH Lejon, John P Morrissey, Fergal O’gara, Alan DW Dobson: ''Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism.'' Marine Drugs 8 (3), 2010; S. 608-628. .</ref> especially of [[sponges]]n (Porifera),<ref name="Baker et al. 2010">P.W. Baker, J. Kennedy, J. Morrissey, Fergal O’Gara, A.D.W. Dobson, Julian Roberto Marchesi: ''Endoglucanase activities and growth of marine‐derived fungi isolated from the sponge Haliclona simulans.'' Journal of Applied Microbiology 108 (5), 2010; S. 1668-1675. .</ref> to which he also wrote several book chapters.<ref name="Kennedy et al. 2013">J. Kennedy, S.A. Jackson, J.P. Morrissey, F. O’Gara, A.D.W. Dobson: ''Marine Invertebrate Animal Metagenomics, Porifera.'' In: ''Encyclopedia of Metagenomics.'' Springer, New York City 2013.</ref><ref name="Jackson et al. 2013">S.A. Jackson, J. Kennedy, L.M. Margassery, B. Flemer, N.D. O’ Leary, J.P. Morrissey, F. O'Gara, A.D.W. Dobson: ''Marine sponges –Molecular Biology and Biotechnology.'' In: ''Handbook of Marine Biotechnology.'' Springer, New York City 2013.</ref>
His current research focus is on the molecular biology and microecology of yeasts and the use of genetically modified yeast cells for industrial biotechnology. Morrissey concentrates on the use of ''[[Kluyveromyces marxianus]]'''.<ref name="Lane & Morrissey 2010">M.M. Lane, J.P. Morrissey: ''[[Kluyveromyces marxianus]]: A yeast emerging from its sister's shadow.'' Fungal Biology Reviews 24 (1), 2010; S. 17–26. .</ref><ref name="Morrissey et al. 2015">John P. Morrissey, Maria M.W. Etschmann, Jens Schrader, Gustavo M. de Billerbeck: ''Cell factory applications of the yeast Kluyveromyces marxianus for the biotechnological production of natural flavour and fragrance molecules.'' Yeast 32 (1), 2015; S. 3-16. .</ref><ref name="Juergens et al. 2017">Hannes Juergens, Javier A. Varela, Arthur R. Gorter de Vries, Thomas Perli, Veronica J.M. Gast, Nikola Y. Gyurchev, Arun S. Rajkumar, Robert Mans, Jack T. Pronk, John P. Morrissey, Jean-Marc G. Daran: ''Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9/gRNA co-expression plasmid.'' FEMS Yeast Researc 18 (3), 2018; S. foy012. .</ref><ref name="Morrissey et al. 2018">J. Morrissey, J. Varela, R. Ortiz, K. Wolfe: ''Adaptation of the yeast Kluyveromyces marxianus to a biotechnological niche.'' New Biotechnology 44, S7.</ref> Among other projects he leads the European research projects YEASTCELL (until 2017),<ref name="yeastcell.eu">[https://yeastcell.eu Official Homepage] of the project „YEASTCELL“, assessed at 1. April 2019.</ref><ref name="YEASTCELL Cordis">''[https://ift.tt/2JVVpiF Yeast Cell Factories: Training Researchers to Apply Modern Post-Genomic Methods In Yeast Biotechnology (YEASTCELL)]'' in the European project database [[CORDIS]], assessed at 1. April 2019.</ref> YEASTDOC<ref name="yeastdoc.eu">[https://yeastdoc.eu Official Homepage] of the project „YEASTDOC“, assessed at 1. April 2019.</ref><ref name="YEASTDOC Cordis">''[https://ift.tt/2UncC8J Yeast Biotechnology Doctoral Training Programme (YEASTDOC)]'' in the European project database [[CORDIS]], assessed at 1. April 2019.</ref> and CHASSY<ref name="chassy.eu">[http://chassy.eu Official Homepage] of the project „CHASSY“, assessed at 1. April 2019.</ref><ref name="CHASSY Cordis">''[https://ift.tt/2K8vW5s Model-Based Construction And Optimisation Of Versatile Chassis Yeast Strains For Production Of Valuable Lipid And Aromatic Compounds (CHASSY)]'' in the European project database [[CORDIS]], assessed at 1. April 2019.</ref> with a focus on yeasts as production organisms.
== Awards and Functions ==
John P. Morrissey is a member of the [[Editorial Board]] of the journal [[FEMS Yeast Research]]. He is also a member and representative for Ireland of the International Commission on Yeasts (ICY) and was elected Chairman of the Eukaryotic Section of the [[Society for General Microbiology]] (SGM) from 2013 to 2017.<ref name="Morrissey UCC" />
== Publications (Selection) ==
John P. Morrissey regularly publishes articles on his research activities in scientific journals. These articles are original research contributions as well as review contributions on central topics of molecular biology and biotechnology<ref name="Morrissey UCC" /><ref name="Google Scholar">[https://ift.tt/2UoBvRf ''Publikationen von J. Morrissey''] at Google Scholar.</ref>
As a selection:
* Yves Henry, Heather Wood, John P. Morrissey, Elisabeth Petfalski, Stephen Kearsey, David Tollervey: ''The 5′ end of yeast 5.8 S rRNA is generated by exonucleases from an upstream cleavage site.'' The EMBO journal 13 (10), 1994; S. 2452–2463. ([https://ift.tt/2UqYZFx full text])
* John P. Morrissey, Anne E. Osbourn: ''Fungal Resistance to Plant Antibiotics as a Mechanism of Pathogenesis.'' Microbiology and Molecular Biology Reviews 63 (3), September 1999; S. 708–724.
* Ultan F. Walsh, John P. Morrissey, Fergal O'Gara: ''Pseudomonas for biocontrol of phytopathogens: from functional genomics to commercial exploitation.'' Current Opinion in Biotechnology 12 (3), 2001; S. 289–295.
* M.M. Lane, J.P. Morrissey: ''[[Kluyveromyces marxianus]]: A yeast emerging from its sister's shadow.'' Fungal Biology Reviews 24 (1), 2010; S. 17–26.
* Jonathan Kennedy, Burkhardt Flemer, Stephen A. Jackson, David P.H. Lejon, John P. Morrissey, Fergal O’Gara, Alan D.W. Dobson: ''Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism.'' Marine Drugs 8 (3), 2010; S. 608–628.
* Leonie Baumann, Arun S. Rajkumar, John P. Morrissey, [[Eckhard Boles]], Mislav Oreb: ''A Yeast-Based Biosensor for Screening of Short- and Medium-Chain Fatty Acid Production.'' ACS Synthetic Biology 7 (11), 2018; pp 2640–2646. .
== References ==
== External links ==
* ''[https://ift.tt/2UwShOt John Morrissey]'', biography at University College Cork (UCC)
* [https://ift.tt/2UoBvRf ''Publikationen von J. Morrissey''] at Google Scholar
* ''[https://ift.tt/2JUcr0u John Morrissey]'' at researchgate.net
[[Category:Living people]]
[[Category:University College Cork]]
[[Category:Irish microbiologists]]
[[Category:Irish geneticists]]
[[Category:Irish biologists]]
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